Sustained-release formulation of doxycycline hyclate for prophylaxis of tick bite infection in a murine model of Lyme borreliosis.
نویسندگان
چکیده
The prophylactic potential of a single injection of sustained-release doxycycline hyclate (Atridox) was compared to that of a single oral dose of doxycycline hyclate in a murine model of Lyme borreliosis. Prophylaxis, as measured by the lack of cultivable spirochetes and demonstrable pathology, was noted for 43% of orally treated mice; in contrast, the sustained-release doxycycline hyclate completely protected mice from infection and resultant pathology.
منابع مشابه
Efficacy of an experimental azithromycin cream for prophylaxis of tick-transmitted lyme disease spirochete infection in a murine model.
As an alternative to oral prophylaxis for the prevention of tick transmission of Borrelia burgdorferi, we tested antibiotic cream prophylactic formulations in a murine model of spirochete infection. A 4% preparation of doxycycline cream afforded no protection, but a single application of 4% azithromycin cream was 100% protective when applied directly to the tick bite site at the time of tick re...
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OBJECTIVES Systemic antibiotic treatment of Lyme borreliosis is effective during the early stages of the infection, while chronic manifestations of the disease may remain refractory and difficult to treat. This study was carried out in order to evaluate the potential of topically applied azithromycin to eliminate the spirochaetal organisms in the skin of the freshly bitten host and thereby prev...
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The association of membranoproliferative glomerulonephritis (MPGN) with Lyme borreliosis has only been reported for the C1q-negative subtype. A 64-year-old male presenting with rising creatinine, nephrotic syndrome and monoarthritis few months after a tick bite was noted to have mixed cryoglobulinaemia, a positive borrelia western blot and 'full-house' pattern MPGN with interstitial granuloma. ...
متن کاملPredicting the risk of Lyme borreliosis after a tick bite, using a structural equation model
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متن کاملLongitudinal study of Lyme borreliosis in a high risk population in Switzerland.
Orienteers from all parts of Switzerland (n = 416) were included in a longitudinal study for Lyme borreliosis. In spring 1986, the seroprevalence was 28.1%. At the beginning of the study, 84.3% of orienteers reported a history of tick bite, and 3.8% reported a past history of Lyme borreliosis. During the first (spring 1986-autumn 1986), second (autumn 1986-spring 1987) and third (spring 1987-au...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 48 7 شماره
صفحات -
تاریخ انتشار 2004